A nurse using USPSTF guidelines is identifying Grade C screenings. Which description applies to Grade C screenings?

• A. Substantial benefit
• B. No benefit
• C. Moderate benefit
• D. Small benefit

Answer: (D)

Grade C means there is a small net benefit from the screening, so the decision to use it should be made selectively based on the individual patient’s situation and preferences. In USPSTF guidance, A corresponds to a high certainty of substantial net benefit, B to at least moderate certainty of a moderate to substantial net benefit, C to a small net benefit, D to no net benefit or harms outweighing benefits, and I when evidence is insufficient. So describing Grade C screenings as having a small benefit fits the idea that they are not universally recommended but may be worthwhile for some patients after discussing risks, benefits, and personal values. Substantial benefit would align with the highest grade, no benefit with the lowest, and a moderate benefit with the B grade.